America’s Game of the Week is a classic NFL rivalry game between the 49ers and Cowboys, two of the most popular franchises in the sport.
The 49ers have had much more success, both head-to-head and historically, with four straight wins against the Cowboys since 2022 and a 21-19-1 record in the series.
Oddsmakers give the road team the edge in the matchup with the spread sitting at Niners -4.
The all-time series numbers between these teams mean nothing for this season, but the Cowboys would be smart to keep them in mind. Dallas is 4-5 this season and can’t afford to fall any further into a hole with the postseason race starting to take shape in…
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